Hypertrophic Scars: What Are They?

(DGIwire) – Not all scars are created equal. While always unsightly, a certain type—known as hypertrophic scars—can be especially bothersome, both physically and psychologically, for those who have them. But what are they, exactly? According to Medscape, hypertrophic scars are characterized by abnormally red, itchy, raised fibrous lesions that typically do not expand beyond the […]

RNA Interference (RNAi) Technology: Cutting-Edge Technology for Immuno-Oncology

(DGIwire) – Sometimes a significant advancement in medicine results from the application of a proven technology in a novel area. In the field of immuno-oncology, as recently reported in Genetic Engineering & Biotechnology News (GEN), a potential path forward could be the use of self-delivering RNAi compounds to treat cancer. RNAi is a naturally occurring […]

Geert Cauwenbergh: A Life Science Leader’s Journey

(DGIwire) – All human lives are filled with twists and turns. The lives of leaders in the life science sector are no exception to this rule. A fascinating example is the life of Dr. Geert Cauwenbergh, who is currently President and CEO of RXi Pharmaceuticals. A recent profile in Life Science Leader recounted the highlights […]

Self-Delivering RNAi Compounds: A Unique Therapy for a Wide Range of Diseases

(DGIwire) – When several biotech companies are pursuing a common goal, the company that eventually winds up in front can usually point to a unique innovation for its success. In the hot research area of RNA interference (RNAi), this secret sauce might be found in the form of something called “self-delivering RNAi” (sd-rxRNA®)—and its innovator, […]

Is Cancer the Next Frontier for a Nobel-winning Therapy?

(DGIwire) – There is no greater reward for a new medical treatment than its successful application across a wide variety of conditions. Consider the evolution of RNA interference (RNAi) since its discovery by Craig C. Mello and Andrew Z. Fire, co-recipients of the Nobel Prize in Physiology and Medicine in 2006 for their discovery. An […]

The Eyes Have It: A Unique Therapy for Ocular Disorders

(DGIwire) – We depend on our vision to complete everyday simple tasks. Unfortunately, there are many ocular disorders that can cause problems in both the front and the back of the eye that interfere with our vision and may prevent our ability to function. The cornea is the eye’s outermost layer, according to the National […]

Could a Tiny Telescope Help Those With Age-Related Macular Degeneration?

(DGIwire) – Neovascular or wet age-related macular degeneration (AMD) is an incurable eye disease that damages the macula, the small area near the center of the retina that contains a high concentration of light receptors, according to the American Academy of Ophthalmology. In “wet” AMD, abnormal blood vessels grow underneath the macula, often leaking fluids […]

RNA Interference: Nobel-Winning Science Coming to Fruition

(DGIwire) – When Craig C. Mello and Andrew Z. Fire were jointly awarded the Nobel Prize in Physiology and Medicine in 2006, the phenomenon for which they were honored—RNA interference (RNAi)—had already been making headlines for years since its initial discovery in 1998. RNAi is a naturally occurring process by which a particular “messenger RNA” […]

Skin Fibrosis: Could RNAi Therapy Fill an Unmet Need?

(DGIwire) – Imagine skin around a healed wound that feels so tight that flexing it becomes a painful chore. Sounds like a nightmare? It is a reality for those with skin fibrosis—a serious condition characterized by the inflammation and hardening of skin tissue, and ultimately tissue dysfunction, reports Scleroderma News. In the most severe cases, […]

RNAi: Turning Off Genes to Treat Disease

(DGIwire) – In high school biology class, students are taught “DNA codes for RNA codes for proteins.” These days, scientists not only have the capability to manipulate the basic molecules of life; they are also able to prevent the production of proteins that play roles in certain diseases. The way this works is through a […]

Vision Problems to Rise as Baby Boomers Age

(DGIwire) – Baby boomers have seen dramatic shifts in society over the past few decades. But as they get older, their ability to see might degrade. In June 2016, the deputy clinical director of the National Eye Institute (NEI), a division of the National Institutes of Health, told the Pocono Record that as the youngest […]

Broccoli and Vision: A Surprising Connection

(DGIwire) – Carrots are supposedly beneficial for eyesight but—broccoli? Researchers from the Buck Institute for Research on Aging, located in Novato, CA, recently boosted the potency of a broccoli-related compound by 10 times and identified it as a possible treatment for age-related macular degeneration (AMD), a leading cause of vision loss affecting more than two […]

Is RNAi the ‘Next Big Thing’ in Consumer Skin Care?

(DGIwire) — When it comes to skin care, many cosmetic products promise a lot…and deliver a lot less. But what if skin care products were able to harness a cutting-edge molecular tool that directly blocked the proteins that trigger problems like uneven skin tone and wrinkles? According to the American Osteopathic College of Dermatology, one […]

RNAi: How One Man Helped Discover a Potential Road to Better Treatments

(DGIwire) – Dr. Craig Mello received the Nobel Prize in Physiology or Medicine in 2006—but he didn’t always want to be a life scientist. Instead, digging for dinosaur bones lured him into science, according to a profile published by the Howard Hughes Medical Institute (HHMI). Mello’s father, a paleontologist with the Smithsonian Institution, often took […]

Age-Related Macular Degeneration: 5 Things to Know

(DGIwire) – Once a person has been diagnosed with age-related macular degeneration (AMD), they are likely to have a lot of questions. An eye care professional who has examined the patient’s eyes and is familiar with his or her medical history is the best person to answer specific questions, but here are some very basic […]

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