3 Challenges Facing Immunotherapy and How RNAi Might Help

(DGwire) – The battle against solid tumors in cancer immunotherapy is engaging some of the brightest minds in medicine. While predictions suggest the immunotherapy market will be worth about $25 billion by 2030, there are still some hurdles to overcome in the effort to improve treatment options, including: Boosting the immune system to fight: As […]

RNAi: Paving the Way to a New Class of Treatments

(DGIwire) – These are exciting times for gene therapy. As Business Insider recently reported, a biopharmaceutical company announced positive results from a late-stage clinical study of a drug for a rare nerve disorder, familial amyloid polyneuropathy. This drug, notes a report in STAT, harnesses a phenomenon called RNA interference (RNAi). This is a naturally occurring […]

CAR-T Cell Therapy: Just the First Step for Immuno-Oncology

(DGIwire) – The U.S. Food and Drug Administration’s recent approval of Novartis’ gene therapy—for the treatment of children and young adults with relapsed or refractory B-cell acute lymphoblastic leukemia—represents a watershed moment for healthcare. As Healio recently reported, Kymriah provides unprecedented benefits to poor prognosis patients who have exhausted all other treatment options. What makes […]

Hypertrophic Scars: What Are They?

(DGIwire) – Not all scars are created equal. While always unsightly, a certain type—known as hypertrophic scars—can be especially bothersome, both physically and psychologically, for those who have them. But what are they, exactly? According to Medscape, hypertrophic scars are characterized by abnormally red, itchy, raised fibrous lesions that typically do not expand beyond the […]

RNA Interference (RNAi) Technology: Cutting-Edge Technology for Immuno-Oncology

(DGIwire) – Sometimes a significant advancement in medicine results from the application of a proven technology in a novel area. In the field of immuno-oncology, as recently reported in Genetic Engineering & Biotechnology News (GEN), a potential path forward could be the use of self-delivering RNAi compounds to treat cancer. RNAi is a naturally occurring […]

Delivering Another Option in Immunotherapy Treatment

(DGIwire) – Within the realm of cancer care, immunotherapy is increasingly occupying the spotlight. And with good reason: as many recent headlines show, this form of therapy holds great promise for improved treatment of a wide variety of cancers. There exist several approaches to immunotherapy, each with its specific strengths. One fascinating approach to immunotherapy, […]

Self-Delivering RNAi Compounds: A Unique Therapy for a Wide Range of Diseases

(DGIwire) – When several biotech companies are pursuing a common goal, the company that eventually winds up in front can usually point to a unique innovation for its success. In the hot research area of RNA interference (RNAi), this secret sauce might be found in the form of something called “self-delivering RNAi” (sd-rxRNA®)—and its innovator, […]

Is Cancer the Next Frontier for a Nobel-winning Therapy?

(DGIwire) – There is no greater reward for a new medical treatment than its successful application across a wide variety of conditions. Consider the evolution of RNA interference (RNAi) since its discovery by Craig C. Mello and Andrew Z. Fire, co-recipients of the Nobel Prize in Physiology and Medicine in 2006 for their discovery. An […]

The Eyes Have It: A Unique Therapy for Ocular Disorders

(DGIwire) – We depend on our vision to complete everyday simple tasks. Unfortunately, there are many ocular disorders that can cause problems in both the front and the back of the eye that interfere with our vision and may prevent our ability to function. The cornea is the eye’s outermost layer, according to the National […]

Could a Tiny Telescope Help Those With Age-Related Macular Degeneration?

(DGIwire) – Neovascular or wet age-related macular degeneration (AMD) is an incurable eye disease that damages the macula, the small area near the center of the retina that contains a high concentration of light receptors, according to the American Academy of Ophthalmology. In “wet” AMD, abnormal blood vessels grow underneath the macula, often leaking fluids […]

RNA Interference: Nobel-Winning Science Coming to Fruition

(DGIwire) – When Craig C. Mello and Andrew Z. Fire were jointly awarded the Nobel Prize in Physiology and Medicine in 2006, the phenomenon for which they were honored—RNA interference (RNAi)—had already been making headlines for years since its initial discovery in 1998. RNAi is a naturally occurring process by which a particular “messenger RNA” […]

Skin Fibrosis: Could RNAi Therapy Fill an Unmet Need?

(DGIwire) – Imagine skin around a healed wound that feels so tight that flexing it becomes a painful chore. Sounds like a nightmare? It is a reality for those with skin fibrosis—a serious condition characterized by the inflammation and hardening of skin tissue, and ultimately tissue dysfunction, reports Scleroderma News. In the most severe cases, […]

Scarred for Life? How Visible Scars Can Impact Quality of Life

(DGIwire) – What are the ramifications of scarring on patients’ quality of life? While some may consider scarring to be merely a cosmetic concern, it can genuinely affect their psychosocial health. This was the conclusion of research presented at the American Academy of Dermatology (AAD) 2016 Summer Meeting in Boston. According to the research, patients […]

The Truth About HPV, Warts and All

(DGIwire) – The human papillomavirus (HPV) is the most common sexually transmitted infection in the U.S., reports the Centers for Disease Control and Prevention (CDC). At least half of sexually active men and women will acquire HPV in their lifetime, according to research published in the journal Sexually Transmitted Diseases. In addition, HPV is associated […]

Vision Problems to Rise as Baby Boomers Age

(DGIwire) – Baby boomers have seen dramatic shifts in society over the past few decades. But as they get older, their ability to see might degrade. In June 2016, the deputy clinical director of the National Eye Institute (NEI), a division of the National Institutes of Health, told the Pocono Record that as the youngest […]

close